A Public Health Problem Of Epidemic Proportions

In addition to the adverse reactions listed in the Physicians' Desk Reference, the FDA published a Public Health Advisory on March 22, 2004 which states (in part): "Anxiety, agitation, panic attacks, insomnia, irritability, hostility, impulsivity, akathisia (severe restlessness), hypomania, and mania have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well as for other indications, both psychiatric and nonpsychiatric." (Click Links button at bottom of this page for a direct link to this FDA Warning.)

Most of the stories on this site describe events which occurred after the year 2000. The increase in online news material and the efficiency of search engines has greatly increased the ability to track stories. Even these 2100+ documented stories only represent the tip of an iceberg since most stories do not make it into the media. There are 45 cases of bizarre behavior, 28 school shootings/incidents, 49 road rage tragedies, 10 air rage incidents, 32 postpartum depression cases, over 500 murders (homicides), over 180 murder-suicides and other acts of violence including workplace violence on this site.

There is a grave concern among advocates that adverse reactions are greatly underestimated by the public, the medical profession and the regulatory authorities. Each of these stories in our list can be interpreted as an adverse reaction and in most cases we have highlighted the portion of the article that refers to evidence of bizarre behavioral change consistent with drug reaction. In some stories causation is acknowledged and the juxtaposition of these stories with those where it goes unrecognized as well as the repetition of themes and circumstances is chilling. If indeed medications played a significant role in all these tragedies, then this is a public health problem of epidemic proportions on a global scale.

Note: SSRI Stories collection of 2100+ new...